Population
In vitro system of purified components
Comparison
Thrombin-thrombomodulin complex vs Free thrombin
Design
Preclinical
Authors
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May link coagulation to fibrinolysis regulation; leaves open physiologic relevance and therapeutic targeting in human thrombosis.
The thrombin-thrombomodulin complex is the likely physiologic activator of TAFI, providing a molecular link where coagulation down-regulates fibrinolysis.
Bajzar et al. (1996) studied this question.
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