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May 1, 1999Journal of Clinical MicrobiologyOpen Access

Laboratory Diagnosis of Common Viral Infections of the Central Nervous System by Using a Single Multiplex PCR Screening Assay

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Why the study?

Does a single multiplex PCR screening assay improve the detection of common viral infections in cerebrospinal fluid compared to previous assays?

Population

1,683 consecutive cerebrospinal fluid (CSF) samples

Comparison

Single multiplex PCR screening assay for herpes… vs Similar assays described previously

Design

Cross-sectional

Authors

SRSteven ReadJKJ. B. Kurtz

Discussion

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Overview

May inform HSV-2 etiology in adult female aseptic meningitis; leaves open whether multiplex PCR should alter routine CSF testing.

Structured PICO

Does a single multiplex PCR screening assay improve the detection of common viral infections in cerebrospinal fluid compared to previous assays?

P
Population
1,683 consecutive cerebrospinal fluid (CSF) samples
I
Intervention
Single multiplex PCR screening assay for herpes simplex virus type 1 (HSV-1), HSV type 2 (HSV-2), varicella-zoster virus (VZV), and enteroviruses
C
Comparator
Similar assays described previously
O
Outcome
Detection of viral nucleic acid (molecular sensitivity and utility)surrogate

A single multiplex PCR assay demonstrates improved sensitivity for detecting common viral causes of meningitis and encephalitis, revealing a high incidence of HSV-2 in adult females with aseptic meningitis.

Cite This Study

Read et al. (1999) studied this question.

synapsesocial.com/papers/6a77086fd8eb58afc2bd92b4https://doi.org/10.1128/jcm.37.5.1352-1355.1999
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