Key result
Prehypertension in young adults was associated with a significantly higher prevalence of left ventricular diastolic dysfunction (14.5% vs 0.5%) and altered left ventricular geometry compared to normotensive controls.
Why the study?
Prehypertension carries an increased risk of cardiovascular morbidity and mortality, which could partly be explained by early compromise in left ventricular structure and function.
Does prehypertension alter left ventricular geometry and function in young adults compared to normotensive controls?
Cross-Sectional (n=400)
No
Does prehypertension alter left ventricular geometry and function in young adults compared to normotensive controls?
Absolute Event Rate: 14.5% vs 0.5%
p-value: p=<0.001
Prehypertension in young adults is associated with early adverse changes in left ventricular geometry and diastolic function, highlighting the need for early cardiovascular risk assessment and management.
Prehypertension may signal early LV changes in young adults; leaves open whether intervention alters progression.
Background: Prehypertension is associated with an increased risk of cardiovascular morbidity and mortality. This risk could partly be explained by the early compromise in left ventricular (LV) structure and function. This study investigated the LV geometry and function in young black prehypertensive subjects. Methods and results: This cross-sectional descriptive study was conducted at the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. Echocardiography-derived LV geometry and function were assessed using standardized methods. Prehypertensive subjects had higher mean systolic blood pressure (BP) (130.78 ± 3.57 mmHg vs 111.42 ± 3.54 mmHg, P<0.001), diastolic BP (79.32 ± 4.13 mmHg vs 66.39 ± 4.42 mmHg, P<0.001), body mass index (BMI) (26.24 ± 3.45 kg/m2 vs 22.20 ± 2.21 kg/m2, P<0.001), waist circumference (WC) (86.93 ± 8.73 cm vs 76.73 ± 6.66 cm, P<0.001), fasting blood glucose (FBG) (93.84 ± 7.28 mg/dl vs 90.08 ± 6.26 mg/dl, P<0.001), and dyslipidemia (21.5% vs 6%. P<0.001) compared to normotensive subjects. LV mass index (LVMI) was greater in prehypertensive subjects compared to normotensive subjects {male (106.84 ± 12.34 g/m2 vs 76.07 ± 10.25 g/m2, P<0.001); female (92.06 ± 8.80 g/m2 vs 66.53 ± 7.21 g/m2, P<0.001)}, with abnormal LV geometry recorded in 17.5%. Linear regression analysis showed that waist circumference, systolic BP, serum creatinine level, and urea level were determinants of LVMI. The prevalence of LV diastolic dysfunction was higher in prehypertensive subjects than in normotensive subjects (14.5% vs. 0.5%, P<0.001), with systolic BP {odds ratio (OR) 0.928, confidence interval (CI) 0.834 - 0.969; P=0.016)} and diastolic BP (OR 0.832, CI 0.722 - 0.958; P=0.011) being independent predictors. Conclusion: This study showed that prehypertension in young Black subjects was associated with altered LV geometry and impaired diastolic function, and these changes demonstrated linear progression with increasing systolic BP.
No takes yet. Share an insight, caveat, or question.
Oboirien et al. (2023) conducted a cross-sectional in Prehypertension (n=400). Prehypertension vs. Normotension was evaluated on Left ventricular diastolic dysfunction (p=<0.001). Prehypertension in young adults was associated with a significantly higher prevalence of left ventricular diastolic dysfunction (14.5% vs 0.5%) and altered left ventricular geometry compared to normotensive controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: