What question did this study set out to answer?

Review the cell biology of leukocyte proteinases and examine the mechanisms through which they support physiological wound healing or induce pathological tissue injury.

November 1, 1999Wound Repair and Regeneration

Leukocyte proteinases in wound healing: roles in physiologic and pathologic processes

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Authors

BBBrooke BarrickBrigham and Women's Hospital ECEdward J. CampbellUniversity of Georgia COCaroline A. OwenMid Cheshire Hospitals NHS Foundation Trust

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Implication

Narrative review reveals leukocyte proteinase dynamics during tissue repair, highlighting cellular mechanisms that bypass extracellular inhibitors to balance physiologic healing and tissue injury.

Key Points

Review the cell biology of leukocyte proteinases and examine the mechanisms through which they support physiological wound healing or induce pathological tissue injury.
Synthesized literature on the cell biology and extracellular behavior of leukocyte-derived proteinases.
Evaluated mechanisms through which proteinases circumvent endogenous extracellular proteinase inhibitors.
Leukocyte proteinases serve critical physiologic functions in orchestrating normal tissue remodeling and wound repair.
Uncontrolled proteinase activity circumvents physiological inhibitor defenses, leading to severe and destructive tissue damage across multiple organ systems.

Cite This Study

Barrick et al. (1999) studied this question.

synapsesocial.com/papers/6a770b59df493903fd1e9f2c https://doi.org/10.1046/j.1524-475x.1999.00410.x

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Implication

Narrative review reveals leukocyte proteinase dynamics during tissue repair, highlighting cellular mechanisms that bypass extracellular inhibitors to balance physiologic healing and tissue injury.

Leukocyte proteinases in wound healing: roles in physiologic and pathologic processes

Discussion

Member takes

Implication

Key Points

Cite This Study

Leukocyte proteinases in wound healing: roles in physiologic and pathologic processes

Discussion

Member takes

Implication

Key Points

Cite This Study

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