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June 1, 1992Annual Review of Biochemistry

Inositol Phosphate Biochemistry

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Authors

PMPhilip W. MajerusKagoshima University

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Implication

Review reveals conserved regulators of organ size and tissue growth in animal models, highlighting critical pathways controlling cellular fate.

Key Points

  • To review the biochemistry and functional significance of evolutionarily conserved signaling cascades, specifically the Hippo pathway, in governing tissue growth and developmental regulation.
  • Synthesized molecular and biochemical evidence on conserved signal transduction networks identified across model organisms, including Drosophila melanogaster.
  • Characterizes the Hippo signaling cascade as an evolutionarily conserved regulator of organ size, cellular proliferation, and fate specification.
  • Identifies key biochemical control points that orchestrate cellular growth dynamics to prevent aberrant tissue expansion.

Cite This Study

Philip W. Majerus (1992) studied this question.

synapsesocial.com/papers/6a770b9d9047b4aa92f6ce6ehttps://doi.org/10.1146/annurev.bi.61.070192.001301
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