Key result
Adipose tissue from FPLD2 patients exhibited significantly larger adipocytes, inflammatory cell infiltration, and impaired adipogenic machinery compared to controls.
Case-Control (n=14)
In FPLD2, the adipogenic machinery is impaired in lipodystrophic fat from lipoatrophic regions, despite a near-normal histological phenotype with low-grade inflammation.
No takes yet. Share an insight, caveat, or question.
Does not support changing FPLD2 management; leaves open whether impaired adipogenesis drives metabolic complications.
Araújo‐Vilar et al. (2011) conducted a case-control in Type 2 familial partial lipodystrophy (FPLD2) (n=14). LMNA mutations (FPLD2) vs. Control subjects was evaluated on Histological characterization and expression of genes and proteins involved in cell cycle control, mitochondrial function, inflammation and adipogenesis. Adipose tissue from FPLD2 patients exhibited significantly larger adipocytes, inflammatory cell infiltration, and impaired adipogenic machinery compared to controls.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: