Why the study?
Does ART-123 activate the protein C pathway and reduce prothrombinase activity in healthy male volunteers?
Does ART-123 activate the protein C pathway and reduce prothrombinase activity in healthy male volunteers?
A 0.3 mg intravenous bolus of ART-123 safely activates the protein C pathway and reduces prothrombinase activity in healthy male volunteers.
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Supports investigation of ART-123 in thrombotic disorders; leaves open whether prothrombinase reduction improves clinical outcomes.
Nakashima et al. (1998) studied this question.
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