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January 1, 1994Thrombosis and Haemostasis

Effects of Recombinant Human Soluble Thrombomodulin (rhs-TM) on a Rat Model of Disseminated Intravascular Coagulation with Decreased Levels of Plasma Antithrombin III

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Key result

Recombinant human soluble thrombomodulin effectively prevented disseminated intravascular coagulation independent of antithrombin III levels, whereas heparin was ineffective in rats with reduced ATIII.

Why the study?

Does recombinant human soluble thrombomodulin (rhs-TM) prevent DIC in a rat model with reduced ATIII levels compared to heparin?

Population

Rat model of disseminated intravascular coagulation induced by tissue factor infusion, with decreased plasma…

Comparison

Recombinant human soluble thrombomodulin (rhs-TM) vs Heparin

Design

Preclinical

Authors

YAYoshikazu AokiNisshin Steel (Japan)RORika OhishiKumiai Chemical Industry (Japan)RTRyoichi TakeiKumiai Chemical Industry (Japan)

Discussion

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Implication

rhs-TM may offer ATIII-independent DIC control in models; leaves open human translation pending trials.

Structured PICO

Does recombinant human soluble thrombomodulin (rhs-TM) prevent DIC in a rat model with reduced ATIII levels compared to heparin?

P
Population
Rat model of tissue factor-induced disseminated intravascular coagulation with reduced antithrombin III levels.
I
Intervention
Recombinant human soluble thrombomodulin (rhs-TM)
C
Comparator
Heparin
O
Outcome
Prevention of DIC (measured by inhibition of decrease in platelet count and fibrinogen level, and prolongation of APTT and PT)surrogate

rhs-TM effectively inhibits coagulation independent of ATIII levels in a rat model of DIC, unlike heparin which depends on ATIII levels.

Cite This Study

Aoki et al. (1994) studied Disseminated intravascular coagulation (DIC) with decreased plasma antithrombin III (ATIII) levels. Recombinant human soluble thrombomodulin (rhs-TM) vs. Heparin was evaluated on Prevention of DIC (inhibition of decrease in platelet count and fibrinogen level). Recombinant human soluble thrombomodulin effectively prevented disseminated intravascular coagulation independent of antithrombin III levels, whereas heparin was ineffective in rats with reduced ATIII.

synapsesocial.com/papers/6a62cdc8809dd4a9e2c19f1chttps://doi.org/10.1055/s-0038-1642459
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Glycosaminoglycan of Recombinant Human Soluble Thrombomodulin Affects Antithrombotic Activity in a Rat Model of Tissue Factor-Induced Disseminated Intravascular Coagulation1992 · 26 citations
  2. 2Pharmacology of heparin and warfarin1986 · 59 citations
  3. 3Serial studies of protein C and its plasma inhibitor in patients with disseminated intravascular coagulation1985 · 143 citations
  4. 4Antithrombotic effect of recombinant human thrombomodulin on thrombin- induced thromboembolism in mice1990 · 138 citations
  5. 5Recombinant Human Soluble Thrombomodulin Delivers Bounded Thrombin to Antithrombin III: Thrombomodulin Associates with Free Thrombin and Is Recycled to Activate Protein C1993 · 30 citations