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January 1, 1998Thrombosis and Haemostasis

Effects of Recombinant Human Soluble Thrombomodulin (rhs-TM) on Clot-induced Coagulation in Human Plasma

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Key result

Recombinant human soluble thrombomodulin attenuated clot growth and clot-induced thrombin generation in human plasma by activating protein C.

Why the study?

Does recombinant human soluble thrombomodulin (rhs-TM) attenuate clot-induced coagulation in human plasma?

Population

Human plasma (in vitro model)

Comparison

Recombinant human soluble thrombomodulin (rhs-TM) vs Argatroban, heparin, Fragmin, and control

Design

Preclinical

Authors

MSMakoto SuzukiAsahi Chemical & Industry (Japan)ESEmika SugimotoAsahi Kasei (Japan)MSM. SataAsahi Kasei (Japan)

Discussion

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Implication

Hypothesis-generating for rhs-TM in human plasma; leaves open translation to clinical thrombosis management.

Structured PICO

Does recombinant human soluble thrombomodulin (rhs-TM) attenuate clot-induced coagulation in human plasma?

P
Population
Human plasma (in vitro model)
I
Intervention
Recombinant human soluble thrombomodulin (rhs-TM)
C
Comparator
Argatroban, heparin, Fragmin (low molecular weight heparin), and control
O
Outcome
Clot-induced coagulation (thrombin generation, fibrinopeptide A production, and clot regrowth)surrogate

Recombinant human soluble thrombomodulin attenuates clot growth in vitro by activating protein C and inhibiting further thrombin generation.

Cite This Study

Suzuki et al. (1998) studied Clot-induced coagulation. Recombinant human soluble thrombomodulin (rhsTM) vs. Argatroban, heparin, and low molecular weight heparin was evaluated on Clot-induced thrombin generation and clot growth. Recombinant human soluble thrombomodulin attenuated clot growth and clot-induced thrombin generation in human plasma by activating protein C.

synapsesocial.com/papers/6aa0ac0d8eabfe21f24f79behttps://doi.org/10.1055/s-0037-1615390
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Inhibitory Effect of Recombinant Human Soluble Thrombomodulin on Initiation and Extension of Coagulation1999 · 61 citations
  2. 2Antithrombotic effects of recombinant human soluble thrombomodulin (rhs‐TM) on arteriovenous shunt thrombosis in rats1994 · 24 citations
  3. 3Effects of Recombinant Human Soluble Thrombomodulin (rhs-TM) on a Rat Model of Disseminated Intravascular Coagulation with Decreased Levels of Plasma Antithrombin III1994 · 45 citations
  4. 4Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates2005 · 9 citations
  5. 5The Glycosaminoglycan of Recombinant Human Soluble Thrombomodulin Affects Antithrombotic Activity in a Rat Model of Tissue Factor-Induced Disseminated Intravascular Coagulation1992 · 26 citations