Why the study?
Does thrombomodulin inhibit fibrinolysis in human plasma?
Population
Human plasma and purified systems
Comparison
Addition of rabbit thrombomodulin, anti-rabbit… vs Plasma without added thrombomodulin or antibodies
Design
Preclinical
Authors
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Thrombomodulin may inhibit fibrinolysis in plasma models; leaves open clinical translation or therapeutic targeting in humans.
Does thrombomodulin inhibit fibrinolysis in human plasma?
Soluble thrombomodulin fragments in human plasma inhibit fibrinolysis through the acceleration of thrombin-dependent activation of plasma procarboxypeptidase B.
Hosaka et al. (1998) studied this question.
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