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November 22, 2005British Journal of Haematology

Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates

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Why the study?

Does recombinant human soluble thrombomodulin reduce thrombus growth in a primate model of acute vascular graft thrombosis?

Population

11 baboons (Papio species) in a primate model of acute vascular graft thrombosis

Comparison

Recombinant human soluble thrombomodulin at 0.1… vs Untreated baboons

Design

Preclinical

Follow-up

3 hours

Authors

KTKenichi A. TanakaUniversity of Maryland, BaltimoreJFJosé A. FernándezScripps Research InstituteUMUlla M. MarzecOregon National Primate Research Center

Discussion

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Implication

Supports protein C-independent antithrombotic effects of rhsTM in primates; leaves open translation to human vascular graft thrombosis.

Structured PICO

Does recombinant human soluble thrombomodulin reduce thrombus growth in a primate model of acute vascular graft thrombosis?

P
Population
11 baboons (Papio species) in a primate model of acute vascular graft thrombosis
I
Intervention
Recombinant human soluble thrombomodulin (rhsTM) at 0.1, 1, and 5 mg/kg, with or without co-injection of a neutralising monoclonal antibody to protein C (HPC4) in the 1 mg/kg rhsTM group
C
Comparator
Untreated baboons
O
Outcome
Thrombus growth in the graft, plasma-activated protein C (APC) levels, coagulation and thrombosis markerssurrogate

The primary antithrombotic activity of recombinant human soluble thrombomodulin appears to be independent of protein C in a primate model of acute vascular graft thrombosis.

Cite This Study

Tanaka et al. (2005) studied this question.

synapsesocial.com/papers/6a81f63f727d3b026660f9dchttps://doi.org/10.1111/j.1365-2141.2005.05855.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Inhibitory Effect of Recombinant Human Soluble Thrombomodulin on Initiation and Extension of Coagulation1999 · 61 citations
  2. 2Antithrombotic effects of recombinant human soluble thrombomodulin (rhs‐TM) on arteriovenous shunt thrombosis in rats1994 · 24 citations
  3. 3Effects of Recombinant Human Soluble Thrombomodulin (rhs-TM) on Clot-induced Coagulation in Human Plasma1998 · 23 citations
  4. 4Effects of Recombinant Human Soluble Thrombomodulin (rhs-TM) on a Rat Model of Disseminated Intravascular Coagulation with Decreased Levels of Plasma Antithrombin III1994 · 45 citations
  5. 5The Glycosaminoglycan of Recombinant Human Soluble Thrombomodulin Affects Antithrombotic Activity in a Rat Model of Tissue Factor-Induced Disseminated Intravascular Coagulation1992 · 26 citations