February 15, 1989BloodOpen Access

Inhibition of platelet-dependent thrombus formation by human activated protein C in a primate model

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Why the study?

Does human activated protein C infusion reduce platelet deposition and thrombus formation in a baboon model of prosthetic vascular grafts?

Population

Baboon model of thrombus formation on prosthetic vascular grafts

Design

Preclinical

Authors

AGAndrás GruberAronora (United States)JGJohn H. GriffinVascular Medicine LHLA HarkerEmory University

Discussion

Member takes

Implication

Hypothesis-generating for APC in prosthetic grafts; leaves open clinical translation and safety in humans.

Structured PICO

Does human activated protein C infusion reduce platelet deposition and thrombus formation in a baboon model of prosthetic vascular grafts?

Population

Baboon model of thrombus formation on prosthetic vascular grafts

Intervention

Infusion of 0.25 to 1.1 mg/kg/h purified, human, activated protein C (APC)

Outcome

Vascular graft platelet deposition and blood clotting (measured by APTT)surrogate

Human activated protein C produces immediate antithrombotic effects under arterial flow conditions in a primate model without impairing normal hemostatic plug formation.

Cite This Study

Gruber et al. (1989) studied this question.

synapsesocial.com/papers/6a9729b87d4622c92c84901a https://doi.org/10.1182/blood.v73.3.639.bloodjournal733639

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Inhibition of platelet-dependent thrombus formation by human activated protein C in a primate model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of platelet-dependent thrombus formation by human activated protein C in a primate model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider