January 1, 1989Journal of Clinical InvestigationOpen Access

Inhibition of activated protein C by platelets.

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Why the study?

Does human platelet releasate inhibit the anticoagulant effects of activated protein C?

Population

Human platelets (in vitro study)

Comparison

Activated protein C in the presence of intact… vs Phospholipid

Design

Preclinical

Authors

SJStephen M. JaneAlfred Health CMChristina A. MitchellDiscovery Institute LHLena HauCho Ray Hospital

Discussion

Member takes

Implication

Does not warrant APC dosing changes; leaves open platelet releasate effects in human thrombosis.

Structured PICO

Does human platelet releasate inhibit the anticoagulant effects of activated protein C?

Population

Human platelets (in vitro study)

Intervention

Activated protein C (APC) in the presence of intact platelets, washed platelet membranes, or platelet releasate

Comparator

Phospholipid

Outcome

Anticoagulant activity of APC (measured by Factor Xa recalcification time, thrombin generation, and rate of inactivation of purified Factor Va)surrogate

Human platelets release a noncompetitive inhibitor of activated protein C upon stimulation, emphasizing their procoagulant role.

Cite This Study

Jane et al. (1989) studied this question.

synapsesocial.com/papers/6a82bb1284489985200f67cb https://doi.org/10.1172/jci113862

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Bookmark

Inhibition of activated protein C by platelets.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of activated protein C by platelets.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider