Why the study?
Does recombinant human soluble thrombomodulin affect antithrombotic activity in a rat model of tissue factor-induced DIC?
Population
Rat model of tissue factor-induced disseminated intravascular coagulation (DIC)
Comparison
Recombinant human soluble thrombomodulin and… vs Comparison between rsTM alpha, rsTM beta, and…
Design
Preclinical
Authors
Loading...
May inform isoform selection for future DIC antithrombotic development; leaves open clinical translation from this rat model.
Does recombinant human soluble thrombomodulin affect antithrombotic activity in a rat model of tissue factor-induced DIC?
In a rat model of DIC, rsTM beta demonstrated more potent antithrombotic activity than rsTM alpha, with both forms showing a wider therapeutic window for bleeding compared to heparin.
Nawa et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: