Why the study?
Does recombinant human soluble thrombomodulin inhibit coagulation in vitro compared to other anticoagulants?
Does recombinant human soluble thrombomodulin inhibit coagulation in vitro compared to other anticoagulants?
Recombinant human soluble thrombomodulin attenuates blood clotting by reducing generated thrombin levels through protein C activation, factor Va inactivation, and prothrombinase inhibition.
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Suggests protein C pathway as anticoagulation target; leaves open translation from animal models to human use.
Sugimoto et al. (1999) studied this question.
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