What question did this study set out to answer?

This study aims to assess the frequency of macroprolactinemia and evaluate the performance of different immunoassay systems in detecting prolactin.

Gross Variability in the Detection of Prolactin in Sera Containing Big Big Prolactin (Macroprolactin) by Commercial Immunoassays

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Randomized trial examines detection variability of prolactin in sera with macroprolactin, suggesting improved screening methods.

This study aims to assess the frequency of macroprolactinemia and evaluate the performance of different immunoassay systems in detecting prolactin.
Analyzed 300 hyperprolactinemic sera to determine the presence of macroprolactin.
Conducted PRL measurements using nine widely used immunoassay systems on untreated sera.
Evaluated the impact of polyethylene glycol treatment on PRL normalization rates.
24% of hyperprolactinemia cases were attributed to macroprolactin.
PRL estimates varied significantly across assay systems, ranging from 2.3- to 7.8-fold differences.
Elecsys assay reported the highest PRL levels, while Access and Centaur systems reported the lowest levels.

Smith et al. (2002) studied this question.

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