Key result
Phosphoglycerate was associated with a higher risk of incident heart failure (OR 1.28 per 1-SD increase, 95% CI 1.06-1.53), whereas no glycolysis metabolites were associated with atrial fibrillation.
Why the study?
The increasing prevalence of AF and HF highlights the need to better understand the mechanisms underlying these cardiovascular diseases.
Are baseline plasma glycolysis intermediates and related metabolites associated with the risk of incident atrial fibrillation and heart failure in an elderly Mediterranean population at high cardiovascular risk?
Case-Control (n=2,088)
Physicians blinded to the intervention group collected information; clinical endpoint adjudication committee was blinded
Yes
Are baseline plasma glycolysis intermediates and related metabolites associated with the risk of incident atrial fibrillation and heart failure in an elderly Mediterranean population at high cardiovascular risk?
Baseline plasma glycolysis metabolites do not predict incident atrial fibrillation in high-risk older adults, though higher baseline phosphoglycerate is modestly associated with increased heart failure risk (particularly in those with diabetes or on a control diet).
Answers are grounded in this paper and cite their sources.
No support for glycolysis metabolites in AF/HF risk stratification; leaves open phosphoglycerate as HF biomarker in high-risk elderly.
The increased prevalence of atrial fibrillation (AF) and heart failure (HF) highlights the need to better understand the mechanisms underlying these cardiovascular diseases (CVDs). In the present study, we aimed to evaluate the association between glycolysis-related metabolites and the risk of AF and HF in a Mediterranean population at high risk of CVD. We used two case–control studies nested within the PREDIMED trial. A total of 512 incident AF cases matched to 734 controls, and 334 incident HF cases matched to 508 controls, were included. Plasma metabolites were quantified by using hydrophilic interaction liquid chromatography coupled with high-resolution negative ion mode MS detection. Conditional logistic regression analyses were performed. The results showed no association between baseline plasma glycolysis intermediates and other related metabolites with AF. Only phosphoglycerate was associated with a higher risk of HF (OR for 1 SD increase: 1.28; 95% CI: 1.06, 1.53). The present findings do not support a role of the glycolysis pathway in the pathogenesis of AF. However, the increased risk of HF associated with phosphoglycerate requires further studies.
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Becerra‐Tomás et al. (2021) conducted a case-control in Atrial fibrillation and heart failure in elderly individuals at high risk of cardiovascular disease (n=2,088). Baseline plasma glycolysis intermediates (including phosphoglycerate) per 1-SD increment vs. Matched controls without incident AF or HF (or lowest quartile / per 1-SD reference) was evaluated on Incident heart failure (and incident atrial fibrillation) (OR 1.28, 95% CI 1.06-1.53). Phosphoglycerate was associated with a higher risk of incident heart failure (OR 1.28 per 1-SD increase, 95% CI 1.06-1.53), whereas no glycolysis metabolites were associated with atrial fibrillation.
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