What question did this study set out to answer?

To determine the impact of craniospinal irradiation on peripheral blood phagocyte function and intracellular bactericidal mechanisms in children with acute lymphoblastic leukemia during remission.

December 6, 1973New England Journal of Medicine

Transient Bactericidal Defect of Peripheral Blood Phagocytes from Children with Acute Lymphoblastic Leukemia Receiving Craniospinal Irradiation

View Full Paper

Ask AI

Bookmark

Authors

RBRobert L. BaehnerChildren's Oncology Group RNRochelle G. NeiburgerUniversity of Missouri–Kansas City DJDouglas E. JohnsonNorthwestern University

Discussion

Member takes

Implication

Longitudinal study demonstrates transient impairment of phagocyte bactericidal activity in children with leukemia undergoing craniospinal irradiation, highlighting temporary infection susceptibility.

Key Points

To determine the impact of craniospinal irradiation on peripheral blood phagocyte function and intracellular bactericidal mechanisms in children with acute lymphoblastic leukemia during remission.
Evaluated 15 pediatric patients (N=15) with acute lymphoblastic leukemia in first remission who received 2400 rads to the craniospinal axis.
Assessed peripheral blood phagocytes across four intervals: before, during, and at two and four weeks following craniospinal irradiation.
Tested in vitro bacterial killing against Staphylococcus aureus, Diplococcus pneumoniae, and Pseudomonas aeruginosa, alongside metabolic assays including oxygen consumption, hexose monophosphate shunt activity, myeloperoxidase activity, and zymosan iodination.
Bacterial engulfment remained intact, but intracellular bactericidal activity against test organisms was impaired during craniospinal irradiation and was not restored by normal serum.
Phagocytic iodination of zymosan was markedly decreased during irradiation, whereas oxygen consumption, hexose monophosphate shunt activity, and myeloperoxidase levels were normal.

Cite This Study

Baehner et al. (1973) studied this question.

synapsesocial.com/papers/6a77188fde5e3adfbdf6efbd https://doi.org/10.1056/nejm197312062892301

View Full Paper

Ask AI

Bookmark

Implication

Longitudinal study demonstrates transient impairment of phagocyte bactericidal activity in children with leukemia undergoing craniospinal irradiation, highlighting temporary infection susceptibility.

Transient Bactericidal Defect of Peripheral Blood Phagocytes from Children with Acute Lymphoblastic Leukemia Receiving Craniospinal Irradiation

Discussion

Member takes

Implication

Key Points

Cite This Study

Transient Bactericidal Defect of Peripheral Blood Phagocytes from Children with Acute Lymphoblastic Leukemia Receiving Craniospinal Irradiation

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider