Prospective registry study reveals age- and season-dependent variations in atopic dermatitis presentations, highlighting distinct clinical subtypes across life stages.
Key Points
To investigate variations in the clinical presentation of atopic dermatitis across different ages, sexes, anatomical sites, and seasons.
Prospective registry analysis of N=3,829 atopic dermatitis patients enrolled in the Chinese Non-selective Registry for AD (CNRAD) across hospital settings from 2020 to 2022.
Assessed demographic variables, lesion distribution and severity, laboratory findings, allergic comorbidities, family history, and trigger factors.
The male-to-female ratio was 0.92 in adolescents and adults but rose to 2.11 in elderly patients, with elderly individuals and males exhibiting higher disease severity.
Anatomical lesion distribution shifted with age, showing reduced cubital and popliteal fossae involvement and a lower frequency of the extrinsic disease subtype in elderly patients relative to younger cohorts.
Analysis identified ten distinct clinical subtypes of atopic dermatitis based on lesion features, with seasonal shifts identified as the predominant trigger of disease flares.