Methodological review highlights progress in computational microRNA target prediction, indicating that experimental validation remains essential to confirm biological relevance.
Given that microRNAs select their targets by nucleotide base-pairing, it follows that it should be possible to find microRNA targets computationally. There has been considerable progress, but assessing success and biological significance requires a move into the 'wet' lab.
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Eric C. Lai (2004) studied this question.
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