Key result
A simulation of skin mitochondrial oxygen tension in circulatory shock showed that mitochondrial oxygen tension is two orders of magnitude higher than classically assumed.
This simulation model demonstrates that skin mitochondrial oxygen tension in circulatory shock is significantly higher than previously assumed, which may inform future clinical trial designs using mitoPo2 as a resuscitation target.
Challenges classical low mitochondrial O2 assumptions in shock; leaves open mitoPo2 as resuscitation target pending trials.
This is the first paper to simulate mitochondrial oxygen tension in skin in circulatory shock. The relationships of mitoPo 2 with parameters of (microcirculatory) oxygen delivery aid in the understanding of noninvasive bedside measurement of mitoPo 2 values and show that mitochondrial oxygen tension is two orders of magnitude higher than classically assumed. The model can be used to enhance clinical trial design investigating mitoPo 2 as a resuscitation target in circulatory shock.
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Hilderink et al. (2023) studied circulatory shock. Simulation of skin mitochondrial Po2 was evaluated on Mitochondrial oxygen tension (mitoPo2). A simulation of skin mitochondrial oxygen tension in circulatory shock showed that mitochondrial oxygen tension is two orders of magnitude higher than classically assumed.
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