Key result
Hypertension in type 2 diabetic patients was associated with significantly elevated levels of biochemical cardiac markers, including CK-MB (76.78 vs 22.78 U/L, p=0.001), compared to normotensive diabetic patients.
Why the study?
To estimate changes in cardiac markers in type 2 diabetic patients with and without cardiovascular changes.
Do cardiac biomarkers differ between type 2 diabetic patients with and without hypertension?
Cross-Sectional (n=240)
No
Do cardiac biomarkers differ between type 2 diabetic patients with and without hypertension?
Cardiac biomarkers such as CK-MB, Troponin-T, and LDH are significantly elevated in type 2 diabetic patients with hypertension compared to those without, suggesting early cardiovascular changes.
Suggests heightened cardiac monitoring in hypertensive type 2 diabetes; hypothesis-generating association leaves open need for prospective validation.
Aim: The aim of this study is to estimate the changes in cardiac markers in type 2 diabetic patients with and without cardiovascular changes. Methods: In this cross -sectional study, 240 patients with diabetes mellitus type 2 were recruited. The biochemical marker of each patient is compared . Blood samples were gathered and processed for the estimation of CK-MB, LDH, trop-t ,uric acid, microalbuminuria and HbA1c. Results: Diabetic individuals had high levels CK-MB, LDH, trop-t and uric acid as compared with and without (CVS)cardiovascular changes in diabetic patients.. Study suggested that cardiac marker levels were significantly increased in hypertensive patients who’s suffering from diabetes mellitus. Conclusion: There is a need for periodic assessment of the cardiac function and biochemical markers in diabetic patients so that patients can take early preventative measures. Early assessment of the cardiac function and biochemical markers provides early warning signals for patients to take additional precautions.
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Singh et al. (2022) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=240). Hypertension vs. Normotensive (without hypertension) was evaluated on CK-MB levels (U/L) (p=0.001). Hypertension in type 2 diabetic patients was associated with significantly elevated levels of biochemical cardiac markers, including CK-MB (76.78 vs 22.78 U/L, p=0.001), compared to normotensive diabetic patients.
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