Key result
Patients with type 2 diabetes and myocardial infarction undergoing elective PCI exhibited significantly elevated levels of atherogenic lipids, glucose, insulin, HbA1c, and HOMA-IR compared to healthy controls.
Why the study?
Are biochemical parameters (lipid profile, glycemic indices, renal and liver function tests) altered in patients with Type 2 Diabetes Mellitus and myocardial infarction undergoing elective PCI compared to healthy controls?
Case-Control (n=100)
No
Are biochemical parameters (lipid profile, glycemic indices, renal and liver function tests) altered in patients with Type 2 Diabetes Mellitus and myocardial infarction undergoing elective PCI compared to healthy controls?
p-value: p=<0.001
Patients with Type 2 Diabetes Mellitus and myocardial infarction undergoing elective PCI exhibit significant derangements in lipid profiles, glycemic indices, and renal function markers compared to healthy controls, highlighting the role of these biochemical parameters in cardiovascular risk.
These derangements may signal elevated cardiometabolic risk in T2DM-MI patients; hypothesis-generating and leaves causal role open for prospective trials.
When blood flow to the heart muscle is impeded, fat and cholesterol build up on the inner wall of the heart, causing coronary heart disease (CHD), myocardial infarction (MI), and sudden cardiac death are just a few of the diseases that can occur in CAD as a result of atherosclerosis. A catheter is used during Percutaneous Coronary Intervention (PCI), also known as angioplasty, a non-surgical procedure to squeeze a balloon or stent into a narrowing area to restore blood flow to the myocardium. Therefore, it is treated with medication to widen or open up the veins in the heart muscle that contain plaque accumulation that results in stenosis in order to avoid the coronary artery blockage from occurring again. The key CVD risk factor is lipid profile and some biochemicals parameters, and each kind these parameters are associated with an increase in the incidence of MI. Anabolic processes, energy metabolism, and blood sugar levels are all controlled by the hormone insulin. Glycosylated hemoglobin (HbA1c) is frequently used to measure the average blood glucose levels of a person based on the age. The resulting values also help to diagnose diabetes mellitus by determining the blood sugar level. Elevated aminotransferase levels indicating liver function, have attracted great concern as potential novel markers of cardiovascular risk assessment. Although blood urea nitrogen (BUN), creatinine (Cr), and electrolytes is not the mainstay of diagnosis in MI patients, they may have a role in providing a more detailed view of the complications and mortality rates.
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Jasim et al. (2023) conducted a case-control in Myocardial Infarction in Type 2 Diabetes Mellitus (n=100). Myocardial infarction and Type 2 Diabetes vs. Healthy individuals was evaluated on Biochemical parameters including lipid profile, glucose, insulin, HbA1c, and HOMA-IR (p=<0.001). Patients with type 2 diabetes and myocardial infarction undergoing elective PCI exhibited significantly elevated levels of atherogenic lipids, glucose, insulin, HbA1c, and HOMA-IR compared to healthy controls.
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