Key result
Elevated AST is linked to a ~24-fold higher risk of MI vs. healthy controls.
Why the study?
The relationship between myocardial infarction and various blood biomarkers was studied to understand MI etiology better.
Case-Control (n=894)
No
Elevated levels of AST and LDL are strongly associated with an increased risk of myocardial infarction.
Answers are grounded in this paper and cite their sources.
Elevated AST and LDL were associated with MI risk in this case-control analysis; leaves open whether these markers add value to existing risk models.
BACKGROUND: Myocardial infarction (MI) as a term for a heart attack happens due to reduced blood flow to heart myocardium and lack of oxygen supply caused by plaques in the interior walls of coronary arteries. With respect to the importance of MI etiology, we aimed to study the relationship of MI and blood examination variables. METHODS: This study was conducted in Mazandaran Heart Center as a hospital-based case-control Comprising 894 participants including 465 cases and 429 controls, individually matched by sex and age. Considered blood markers were analyzed using routine laboratory methods and equipment. RESULTS: Of all participants, 64.3% of the cases and 51.0% of the controls were males with a mean age of 61.2 (±13.8) in cases and 62.4 (±14.) in controls. We could not find any differences between cases and controls for total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and alkaline-phosphatase (ALP) (P>0.05). However, levels of creatine-kinase-muscle/brain (CK-MB) (P<0.0001), fasting-blood-sugar (FBS) (P<0.0001), aspartate-aminotransferase (AST) (P<0.0001), alanine-transferase (ALT) (P<0.0001) and erythrocyte sedimentation rate (ESR) (P=0.001) were significantly higher in cases compared to the controls (P<0.05). Multivariable analyses revealed that the risk of MI was associated with high levels of AST (adjusted OR=24.3, 95%CI=3.5±165.6, P=0.001) and LDL (adjusted OR=7.4, 95%CI=1.0±51.8, P=0.001). CONCLUSION: Our investigation indicated that the levels of CK-MB, FBS, AST, ALT and ESR were significantly higher in patients with MI. Besides, our findings showed that the risk of MI in cases with high levels of AST and LDL was about 24 and 7 times more than the control group respectively.
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Shamshirian et al. (1970) conducted a case-control in Myocardial Infarction (n=894). High levels of aspartate aminotransferase (AST) vs. Healthy controls was evaluated on Risk of myocardial infarction associated with high levels of AST (OR 24.366, 95% CI 3.583-165.697, p=0.001). High levels of aspartate aminotransferase (AST) were significantly associated with an increased risk of myocardial infarction compared to healthy controls (adjusted OR 24.366).
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