Key result
Acute MI is linked to ~7-fold higher CK-MB and elevated LDH levels versus healthy controls.
Why the study?
The study was conducted to estimate levels of CK-MB, CRP, and LDH biomarkers in troponin T-positive myocardial infarction and compare them with normal healthy individuals.
Are levels of CK-MB, CRP, and LDH elevated in patients with acute myocardial infarction compared to healthy controls?
Cross-Sectional (n=172)
No
Are levels of CK-MB, CRP, and LDH elevated in patients with acute myocardial infarction compared to healthy controls?
Absolute Event Rate: 111.94% vs 16.36%
p-value: p=<0.0001
CK-MB and LDH are significantly elevated in patients with acute myocardial infarction, confirming their utility as sensitive cardiac markers.
CK-MB and LDH elevations may aid AMI identification; leaves open incremental benefit over troponins in modern practice.
Objectives: The aim of this study is to estimate the level of creatine kinase-myocardial band (CK-MB), C-reactive protein (CRP), and lactate dehydrogenase (LDH) biomarker in myocardial infarction (MI) (troponin T-positive) and compare with normal healthy individuals (Troponin-T [TnT] negative). Methods: A cross-sectional study on 172 patients involving 100 patients with nondiabetic MI and 72 apparently healthy controls with no history of diabetes and/or MI was done from December 2017 to May 2018. The diagnosis of MI was established with electrocardiogram findings and TnT estimation. Blood samples were gathered and processed for the estimation of CK-MB, LDH, and CRP. Results: The mean age of the cases was 62.15±7.75 years and in the controls was 61.49±8.35 years (p=0.592). The mean value of CK-MB, LDH, and CRP in the TnT positive group was 111.94±29.59 IU/L, 564.43±110.99 IU/L, and 15.69±4.04 mg/L, whereas in the TnT negative group was 16.36±3.77 IU/L, 223.68±36.23 IU/L, and 6.08±2.02 mg/L, respectively (p<0.0001). CK-MB was deranged in 100% of TnT positive group, and in only 2.78% in TnT negative group (p<0.0001). LDH was deranged in 100% TnT positive group, and in 16.67% in TnT negative group (p<0.0001). CRP was deranged in 4% TnT positive group, and in 0% in TnT negative group (p=0.141). Conclusion: This study indicated that CK-MB and LDH are sensitive cardiac markers for the diagnosis of MI.
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Kumar et al. (2019) conducted a cross-sectional in Acute Myocardial Infarction (n=172). Myocardial infarction (Troponin T positive) vs. Healthy controls (Troponin T negative) was evaluated on Mean CK-MB level (IU/L) (p=<0.0001). Patients with acute myocardial infarction had significantly higher mean CK-MB levels (111.94 vs 16.36 IU/L) and LDH levels compared to healthy controls (p<0.0001).
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