Key result
Myocardial infarction was associated with significantly higher levels of triglycerides (201.4 vs 142.8 mg/dl), fasting blood sugar, and AST, and lower HDL compared to healthy controls.
Why the study?
Does myocardial infarction affect the levels of lipid profile, enzymatic markers, fasting blood sugar, urea, creatinine, and total serum bilirubin compared to healthy controls?
Case-Control (n=60)
No
Does myocardial infarction affect the levels of lipid profile, enzymatic markers, fasting blood sugar, urea, creatinine, and total serum bilirubin compared to healthy controls?
Absolute Event Rate: 201.4% vs 142.8%
p-value: p=≤0.05
Myocardial infarction is associated with significant alterations in biochemical parameters, including elevated triglycerides, AST, fasting blood sugar, urea, and creatinine, and decreased HDL compared to healthy controls.
These MI-associated biochemical shifts should not alter management; leaves open causality and needs prospective confirmation.
Myocardial infarction (MI) continues to be a major cause of mortality and also death at early ages all over the world. This study is undertaken to evaluate the effect of MI on the levels of lipid profile, two enzymatic markers, fasting blood sugar (FBS), urea, creatinine and total serum bilirubin (TSB), rather than to assess the risk factors which lead to MI and its relation to these variables. The sample of the study consisted of (50) patients admitted to the Cardiac Care Unit in Al-Ramadi General hospital. MI patients had significantly (P≤0.05) higher levels of triglyceride (TG) (201.4 mg/dl) as compared with the controls (142.8 mg/dl), while high density lipoprotein (HDL) significantly (P≤0.05) decreased in patients (42.24 mg/dl) compared with control group (58.7mg/dl). Total cholesterol (TC) (183.6 mg/dl) and low density lipoprotein (LDL) (109.3mg/dl) were not affected significantly (P≤0.05) in MI group when compared with control group with the average of (172.2 mg/dl), (116 mg/dl) respectively. Aspartate aminotransferase (AST) increased significantly (P≤0.05) in patients (61.38 IU/L) compared to the control group (23.5 IU/L) , while there was no significant (P≤0.05) difference in alkaline phosphatase (ALP) between MI and control group. Levels of fasting blood sugar (FBS) in the serum of MI group (206 mg/dl) increased significantly (P≤0.05) comparing with the control group (122.1 mg/dl). This study showed increase in urea (55.6 mg/dl) and creatinine (1.26 mg/dl) levels in the MI group contrast with the control group which its mean was (29.8 mg/dl), ( 0.85 mg/dl) respectively. There was no difference in the level of TSB. Findings of this study, stating differences in levels of some biochemical parameters can use as a biomarker of myocardial infarction. There is an increase in the incidence of myocardial infarction and some differences in the level of parameters in the presence of one or more major risk factors.
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Marwan Mahmood Saleh (2017) conducted a case-control in Myocardial Infarction (n=60). Myocardial Infarction vs. Healthy controls was evaluated on Triglyceride (TG) levels (mg/dl) (p=≤0.05). Myocardial infarction was associated with significantly higher levels of triglycerides (201.4 vs 142.8 mg/dl), fasting blood sugar, and AST, and lower HDL compared to healthy controls.
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