Key result
Myocardial oxygen consumption, measured by pressure-volume area, was significantly higher in septic rats on ECMO compared to healthy rats on ECMO.
Why the study?
ECMO may be a viable salvage therapy in selected patients with septic shock, but left ventricular hemodynamics during sepsis with and without ECMO required investigation.
Does extracorporeal membrane oxygenation (ECMO) alter left ventricular performance and myocardial oxygen consumption in a murine model of sepsis?
Does extracorporeal membrane oxygenation (ECMO) alter left ventricular performance and myocardial oxygen consumption in a murine model of sepsis?
Absolute Event Rate: 1.4% vs 0.6%
p-value: p=<0.01
In a murine model of septic shock, ECMO support significantly increased myocardial oxygen consumption and was associated with diastolic dysfunction.
May indicate higher myocardial workload on ECMO in sepsis; leaves open human relevance and optimal support strategies.
Extracorporeal membrane oxygenation (ECMO) may be a viable salvage therapy in selected patients with septic shock. As ECMO use increases, we studied left ventricular (LV) performance during sepsis with and without ECMO using a pressure-volume (PV) loop in a murine model and aimed to understand LV hemodynamics in septic shock with ECMO. The rats were divided into Group 1 (ECMO applied to healthy rats), Group 2 (ECMO for septic rats), Group 3 (Controls, n = 20) and Group 4 (Sepsis induction only, n = 20). The cardiac parameters include end-diastolic volume (EDV), end-systolic volume (ESV), end-diastolic pressure (EDP), and end-systolic pressure (ESP), ejection fraction (EF), end-systolic elastance (Ees), diastolic time constant (Tau) index, arterial elastance (Ea), pressure-volume area (PVA), stroke work (SW), and potential energy (PE). We compared the changes of parameters in all groups. A total of 74 rats were included in the analyses. After 2 h on ECMO, Group 2 was associated with significant increases in ESP, EDV, ESV, PVA, PE, and SW. The difference ratio of PE and PVA was significantly higher in Group 2 compared to Group 1 (P < 0.01). In conclusion, myocardial oxygen consumption was higher in septic shock with ECMO than in controls.
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Kayumov et al. (2022) studied Sepsis and extracorporeal membrane oxygenation (ECMO) (n=74). Extracorporeal membrane oxygenation (ECMO) in septic shock vs. ECMO in healthy rats was evaluated on Change ratio of pressure-volume area (PVA, surrogate for myocardial oxygen consumption) (p=<0.01). Myocardial oxygen consumption, measured by pressure-volume area, was significantly higher in septic rats on ECMO compared to healthy rats on ECMO.
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