Why the study?
Does pre-operative intravenous ketorolac reduce postoperative pain and morphine consumption compared to postoperative administration or placebo in patients undergoing total hip replacement?
Population
60 patients undergoing total hip replacement (THR) under general anesthesia
Comparison
Intravenous ketorolac 60 mg administered before… vs Intravenous ketorolac 60 mg administered after…
Design
RCT, randomly allocated to 3 groups, double-blind
Follow-up
2 days
Authors
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Pre-operative ketorolac should be prioritized for immediate post-THR analgesia; confirms timing-dependent benefit over postoperative dosing in this RCT.
Does pre-operative intravenous ketorolac reduce postoperative pain and morphine consumption compared to postoperative administration or placebo in patients undergoing total hip replacement?
Pre-operative administration of intravenous ketorolac provides superior immediate postoperative analgesia compared to administration at skin closure for total hip replacement, though the effect is not sustained over time.
Fletcher et al. (1995) studied this question.
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