Cardiovascular effects of acute hyperglycaemia: pathophysiological underpinnings
Key result
Acute hyperglycaemia after acute myocardial infarction is associated with an increased risk of death and may favor cardiovascular disease through the generation of oxidative stress.
Population
Subjects with myocardial infarction and concomitant acute hyperglycaemia (with and without diabetes)
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
Warrants glucose monitoring after MI; leaves open whether targeting hyperglycaemia improves outcomes via oxidative stress reduction.
Key Points
- To review the toxic cardiovascular effects and pathophysiological mechanisms underlying the poor prognosis associated with acute hyperglycaemia after acute myocardial infarction.
- Reviewed clinical and experimental literature regarding admission blood glucose levels in acute myocardial infarction.
- Synthesized mechanistic pathways linking acute hyperglycaemia and oxidative stress to adverse cardiovascular outcomes in patients with and without diabetes.
- High admission blood glucose levels after acute myocardial infarction are common and consistently associated with an increased risk of death in both diabetic and non-diabetic populations.
- Acute hyperglycaemia exerts toxic effects on the cardiovascular system primarily by generating oxidative stress, which accelerates cardiovascular damage and worsens prognosis.
Structured PICO
P
Population
Subjects with myocardial infarction and concomitant acute hyperglycaemia (with and without diabetes)
This review highlights that acute hyperglycaemia during myocardial infarction may worsen prognosis by promoting oxidative stress.
Cite This Study
Antonio Ceriello (2008) conducted a review in Acute myocardial infarction with concomitant hyperglycaemia. Acute hyperglycaemia was evaluated. Acute hyperglycaemia after acute myocardial infarction is associated with an increased risk of death and may favor cardiovascular disease through the generation of oxidative stress.