Key result
Women with congenital heart diseases had a significantly lower rate of live births (IRR 0.74) and overall fertility compared to matched women without congenital heart diseases.
Why the study?
The objective was to evaluate the fertility of Taiwanese women with congenital heart diseases (CHDs) and investigate how different forms of CHDs influence fertility.
Does congenital heart disease reduce live birth and fertility rates in women of reproductive age?
Cohort (n=13,204)
Yes
Does congenital heart disease reduce live birth and fertility rates in women of reproductive age?
Relative Risk: 0.74 (95% CI 0.71–0.78)
Absolute Event Rate: 313.2% vs 423.1%
p-value: p=<0.001
Women with congenital heart disease have significantly lower live birth and fertility rates compared to matched controls, emphasizing the need for early multidisciplinary reproductive counseling.
May warrant preconception counseling in congenital heart disease; leaves open causal mechanisms and intervention effects.
Background: The objective of this research was to evaluate the fertility of Taiwanese women with diagnoses of congenital heart diseases (CHDs). The study also investigated how different forms of CHDs may have variously influenced fertility. Methods: We directed this nationwide, population-based and retrospective matched-cohort research by using data from the Taiwan National Health Insurance Research Database. The CHD group ( n = 6602) included women with congenital structural heart diseases, aged 16–45 years in 2000. The non-CHD group ( n = 6602) was matched according to urbanization and income. The outcomes, involving live birth, abortion, and fertility rates, were followed until the end of 2013. Poisson regression was used to evaluate the incidence rate ratios (IRRs). Results: The CHDs had an inferior rate of live births (IRR 0.74 [95% CI 0.71–0.78]) than the non-CHD group. There was also a lower fertility rate in the CHD group (IRR 0.81 [95% CI 0.78–0.84]) than the non-CHD group. Abortion rates between the two groups were similar. Conclusion: Congenital structural heart disease compromises female fertility, even among patients with simple forms of CHDs. It is suggested that pregnant patients with CHDs are early appeared to and advised personally with multidisciplinary care to improve their outcomes.
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Chien et al. (2021) conducted a cohort in Congenital heart diseases (n=13,204). Congenital heart diseases vs. Matched women without congenital heart diseases was evaluated on Live births (IRR 0.74, 95% CI 0.71-0.78, p=<0.001). Women with congenital heart diseases had a significantly lower rate of live births (IRR 0.74) and overall fertility compared to matched women without congenital heart diseases.
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