Key result
Insulin resistance is a central metabolic feature of polycystic ovary syndrome, and integrative treatments combining inositols and alpha-lipoic acid show potential in improving insulin sensitivity.
Why the study?
Insulin resistance frequently occurs in PCOS independent of body weight, motivating a review of recent insights to better understand this metabolic impairment.
Insulin resistance is a key pathophysiological feature of PCOS independent of body weight, and integrative treatments like inositols and alpha-lipoic acid may improve metabolic and reproductive outcomes.
Hypothesis-generating for inositols plus alpha-lipoic acid in PCOS insulin resistance; randomized trials needed before clinical adoption.
Polycystic ovary syndrome (PCOS) is a very frequent disease that affects reproductive ability and menstrual regularity. Other than the criteria established at the Rotterdam consensus, in these last few years a new issue, insulin resistance, has been found frequently, and at a very high grade, in patients with PCOS. Insulin resistance occurs for several factors, such as overweight and obesity, but it is now clear that it occurs in patients with PCOS with normal weight, thus supporting the hypothesis that insulin resistance is independent of body weight. Evidence shows that a complex pathophysiological situation occurs that impairs post-receptor insulin signalling, especially in patients with PCOS and familial diabetes. In addition, patients with PCOS have a high incidence of non-alcoholic fatty liver disease related to the hyperinsulinaemia. This narrative review focuses on the recent new insights about insulin resistance in patients with PCOS, to better understand the metabolic impairment accounting for most of the clinical signs/symptoms of PCOS.
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Genazzani et al. (2023) conducted a review in Polycystic Ovary Syndrome. Inositols and Alpha-lipoic acid was evaluated. Insulin resistance is a central metabolic feature of polycystic ovary syndrome, and integrative treatments combining inositols and alpha-lipoic acid show potential in improving insulin sensitivity.
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