Why the study?
Does the presence of mesenchymal stem cells in a ventricular myocyte coculture model increase the risk of reentrant arrhythmias?
Does the presence of mesenchymal stem cells in a ventricular myocyte coculture model increase the risk of reentrant arrhythmias?
In an in vitro model, mixtures of mesenchymal stem cells and ventricular myocytes produced an arrhythmogenic substrate, highlighting a potential proarrhythmic risk of cellular cardiomyoplasty.
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MSCs at 10-20% density promote reentry in myocyte cocultures; leaves open proarrhythmic risk of cellular cardiomyoplasty in vivo.
Chang et al. (2006) studied this question.
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