March 1, 1994British Journal of Haematology

A comparative study of partial primary structures of the catalytic region of mammalian protein C

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Population

Genomic DNA from six mammalian species and known sequences from humans, bovine, and rat

Design

Preclinical

Authors

MMMasahiro MurakawaFukushima Medical University TOTakashi OkamuraKwansei Gakuin University TKTakumi KamuraNagoya University

Discussion

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Implication

Highlights conserved Protein C residues for variant assessment; extends cross-species data but leaves open human clinical translation.

Structured PICO

Population

Genomic DNA from six mammalian species (rhesus monkey, dog, cat, goat, horse, mouse) and known sequences from humans, bovine, and rat

Intervention

Enzymatic amplification and sequencing of PROC gene fragments

Outcome

Nucleotide and amino acid sequence homology of the catalytic region of PROC

The high evolutionary conservation of the Protein C catalytic domain across mammalian species highlights the functional importance of these residues, providing insights into human abnormal PROC variants.

Cite This Study

Murakawa et al. (1994) studied this question.

synapsesocial.com/papers/6a772fbd3da069e66cbd8857 https://doi.org/10.1111/j.1365-2141.1994.tb04791.x

View Full Paper

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A comparative study of partial primary structures of the catalytic region of mammalian protein C

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A comparative study of partial primary structures of the catalytic region of mammalian protein C

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider