Key result
Peptidyl aldehyde NK-1.8k inhibited the proliferation of EV71 and EV68 strains with a 50% effective concentration of 90 nM and a selective index over 2,000.
Population
In vitro models of Enterovirus 71 (multiple strains) and Enterovirus 68 (one strain)
Design
Preclinical
Authors
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May inform enterovirus antiviral development; leaves open clinical translation pending in vivo and human studies.
Effect estimate: EC50 90 nM
The peptidyl aldehyde NK-1.8k demonstrates potent in vitro antiviral activity against EV71 and EV68 by targeting protease 3C, highlighting its potential as a therapeutic candidate.
Wang et al. (2015) studied Enterovirus 71 and Enterovirus 68 Infection. Peptidyl Aldehyde NK-1.8k was evaluated on Inhibition of viral proliferation (EC50 90 nM). Peptidyl aldehyde NK-1.8k inhibited the proliferation of EV71 and EV68 strains with a 50% effective concentration of 90 nM and a selective index over 2,000.
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