What question did this study set out to answer?

To identify clinical risk factors and pathological mechanisms underlying intrauterine transmission of hepatitis B virus across the placental barrier.

March 13, 2002Journal of Medical Virology

Risk factors and mechanism of transplacental transmission of hepatitis B virus: A case‐control study

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Authors

DXDe‐Zhong XuBeijing Normal University YYYongping YanUnion Hospital BCBernard C. K. ChoiUniversity of California, Irvine

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Implication

Case-control study identifies maternal viremia and placental endothelial infection as risk factors for intrauterine HBV transmission, suggesting transplacental cellular transfer.

Key Points

To identify clinical risk factors and pathological mechanisms underlying intrauterine transmission of hepatitis B virus across the placental barrier.
Conducted a case-control study nested within a cohort of 402 newborn infants from 402 HBsAg-positive mothers, comparing 15 infants with intrauterine HBV infection (cases) against non-infected controls.
Analyzed 101 full-term placentas from HBsAg-positive mothers and 14 from HBsAg-negative mothers using immunohistochemical staining and HBV DNA in situ hybridization to map viral spread across placental layers.
Intrauterine HBV transmission was significantly associated with maternal HBeAg positivity (OR = 17.07, 95% CI 3.39–86.01) and threatened preterm labor (OR = 5.44, 95% CI 1.15–25.67).
Fetal infection risk increased with maternal serum HBsAg titers (trend test P = 0.0117) and HBV DNA levels (trend test P < 0.01), while placental infection rates decreased progressively from the maternal to fetal layers (trend test P = 0.0009).
Viral infection in placental villous capillary endothelial cells was strongly correlated with intrauterine transmission (OR = 18.46, P = 0.0002).

Cite This Study

Xu et al. (2002) studied this question.

synapsesocial.com/papers/6a773418c5ab23c76cec79e1 https://doi.org/10.1002/jmv.2187

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Implication

Case-control study identifies maternal viremia and placental endothelial infection as risk factors for intrauterine HBV transmission, suggesting transplacental cellular transfer.

Risk factors and mechanism of transplacental transmission of hepatitis B virus: A case‐control study

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Implication

Key Points

Cite This Study

Risk factors and mechanism of transplacental transmission of hepatitis B virus: A case‐control study

Discussion

Member takes

Implication

Key Points

Cite This Study

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