Key result
Simvastatin reduced high glucose-induced apoptosis of mesangial cells and attenuated urinary protein secretion in diabetic rats by preventing the downregulation of Wnt/beta-catenin signaling.
Population
In vitro: mesangial cells cultured in 35 mM glucose. In vivo: streptozocin-induced diabetic rats.
Comparison
Simvastatin pretreatment and administration for… vs Control
Design
Preclinical
Follow-up
28 days (in vivo)
Authors
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Does not support clinical use in diabetic nephropathy; hypothesis-generating for Wnt/beta-catenin modulation in mesangial protection.
Simvastatin prevents high glucose-induced mesangial cell apoptosis by restoring Wnt/beta-catenin signaling, suggesting a protective mechanism in diabetic nephropathy.
Lin et al. (2007) studied Diabetic nephropathy. Simvastatin vs. Control (no simvastatin) was evaluated on Apoptosis and Wnt/beta-catenin signaling. Simvastatin reduced high glucose-induced apoptosis of mesangial cells and attenuated urinary protein secretion in diabetic rats by preventing the downregulation of Wnt/beta-catenin signaling.
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