Primary amenorrhea requires systematic endocrine evaluation before empirical hormonal therapy. In adolescents with hypergonadotropic hypogonadism, prompt karyotype analysis is essential to identify 46,XY complete gonadal dysgenesis (Swyer syndrome), enabling timely prophylactic gonadectomy, preventing gonadal malignancy, and improving endocrine, reproductive, and long-term clinical outcomes.
No takes yet. Share an insight, caveat, or question.
Elendu et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: