Massive induction of apoptosis of multicellular tumor spheroids by a novel compound with a calmodulin inhibitor-like mechanism

Introduction It is well known that a significant discrepancy exists between the efficacy of anticancer drugs in vitro and in vivo [1]. This discrepancy could, in part, be due to the three dimensional (3-D) nature of tumors as compared to the two dimensional (2-D) nature of standard cell culture systems. To