Key result
ACTH 1-24 infusion decreased baroreflex sensitivity from ~18 mmHg/ms to 15 mmHg/ms in healthy subjects, implicating the hypothalamic-pituitary-adrenal axis in hypoglycemia-associated autonomic failure.
Why the study?
Does ACTH infusion decrease baroreflex sensitivity in healthy subjects?
Does ACTH infusion decrease baroreflex sensitivity in healthy subjects?
Absolute Event Rate: 15% vs 18%
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ACTH infusion decreases baroreflex sensitivity, suggesting the hypothalamic-pituitary-adrenal axis plays a role in the baroreflex impairment seen in hypoglycemia-associated autonomic failure.
Sam Dagogo‐Jack (2020) conducted an editorial in Hypoglycemia-Associated Autonomic Failure. ACTH 1-24 (cosyntropin) infusion vs. Placebo was evaluated on Baroreflex sensitivity. ACTH 1-24 infusion decreased baroreflex sensitivity from ~18 mmHg/ms to 15 mmHg/ms in healthy subjects, implicating the hypothalamic-pituitary-adrenal axis in hypoglycemia-associated autonomic failure.
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