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Epidemiological evidences show that SARS-CoV-2 infection in children is less frequent and severe than adults. Age-related ACE2 receptor expression, lymphocyte count and trained immunity might be the keystone to reveal children's secret. On March 11, 2020, a novel human coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become pandemic [1]. By March 24, 372.757 SARS-CoV-2 confirmed cases and 16.231 related deaths have been reported worldwide [2]. In Italy, 62.844 cases and 5.542 deaths have been reported, mostly in northern regions. Detailed data are updated by the Italian National Institute of Health [3].
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Cristiani et al. (2020) studied this question.
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