Key result
Hypertension was strongly associated with chronic kidney disease, present in 86.84% of CKD patients compared to 9% of controls (OR 66.73).
Why the study?
Chronic kidney disease is an escalating global health problem driven by rising risk factors, prompting an assessment of CKD risk factors and public awareness in Taif, Saudi Arabia.
Case-Control (n=1,056)
No
Odds Ratio: 66.73 (95% CI 45.19–98.54)
Absolute Event Rate: 86.84% vs 9%
p-value: p=<0.00001
Major cardiovascular risk factors like hypertension and diabetes are strongly associated with CKD in this Saudi cohort, highlighting a critical need for public health education given the poor baseline knowledge of the disease.
Introduction: Chronic kidney disease (CKD) is a worldwide public health problem since the rapid increasing prevalence of relevant risk factors, like diabetes, hypertension, unhealthy diet, low to no physical activity and metabolic syndrome. The current study aimed at assessing the risk factors and the general public awareness of CKD in Taif region, Saudi Arabia. Method: We conducted a cross-sectional study during the period of September 2019 to March 2020. For risk factors assessment data regarding CKD cases were collected from the department of nephrology at AL-Hada Military hospital in Taif. An online-based questionnaire was distributed to the general public for knowledge assessment of CKD. 6th year pharmacy student at Taif University and nephrologists from the hospital were also invited to answer the questionnaire. Results: The data of 456 CKD patients with 600 non-CKD individuals were compared for assessment of the most common risk factors. 99% of participants were CKD stage III-V patients. The majority, n=371(81.57%), of the participants were >50 years old. N=328(71.93%) had type 2 diabetes mellitus (Risk ratio= 2.32, CI= 2.03-2.65; Odd ratio=5.7, CI= 4.36-7.45), n=396(86.84%) had hypertension (Risk ratio =9.65,CI-7.46-12.48; Odd ratio: 66.73, CI=45.19-98.54) and n=264(57.89%) had a history of heart diseases (Risk ratio= 3.62, CI=2.96-4.42; Odd ratio= 7.22, CI= 5.42-9.62). In CKD groups, 28.07% of them had low physical activity. In contrast with the control group, only 4% had low physical activity level in their daily routine (p<0.00001). In the general public (n=1419), 919 (64.7%) had poor knowledge, 273 (19.22%) had fair knowledge, and 227 respondents (16.01%) had good knowledge of CKD. Conclusion: The finding suggests that age >50 years, low educational attainment, family history of CKD, diabetes, hypertension, history of kidney stone, CVD and high BMI were significantly associated with CKD progression. We also found that the majority of the general public had poor knowledge of CKD compared to pharmacy graduates and nephrologists. These findings warrant the need for the development of awareness initiatives and programs designed to increase the level of knowledge of the general public of CKD.
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Sultana et al. (2020) conducted a case-control in Chronic kidney disease (n=1,056). Hypertension vs. Absence of hypertension was evaluated on Presence of chronic kidney disease (OR 66.73, 95% CI 45.19-98.54, p=<0.00001). Hypertension was strongly associated with chronic kidney disease, present in 86.84% of CKD patients compared to 9% of controls (OR 66.73).
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