Broad‐spectrum matrix metalloproteinase inhibitor marimastat–induced musculoskeletal side effects in rats

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Why the study?

Does marimastat induce musculoskeletal syndrome in male Lewis rats?

Population

Male Lewis rats weighing 150-180 gm

Design

Preclinical, 2 blinded observers using 3 clinical parameters

Follow-up

2 weeks

Authors

Discussion

Establishes rat model replicating human marimastat-induced MSS; hypothesis-generating and leaves clinical translation open.

Does marimastat induce musculoskeletal syndrome in male Lewis rats?

Population

Male Lewis rats weighing 150-180 gm

Intervention

10-30 mg of the broad-spectrum MMP inhibitor marimastat over a 2-week period via surgically implanted subcutaneous osmotic pumps

Outcome

Onset and severity of musculoskeletal syndrome (MSS) using clinical and histologic parameterssafety

This study establishes a simple and sensitive rat model for studying marimastat-induced musculoskeletal syndrome, mimicking human pathology.

Renkiewicz et al. (2003) studied this question.

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