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March 1, 2001Journal of VirologyOpen Access

Interaction of Coxsackievirus A21 with Its Cellular Receptor, ICAM-1

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Population

Coxsackievirus A21 (CAV21) and five-domain ICAM-1 receptor (preclinical structural model)

Comparison

Cryoelectron microscopy image reconstruction of… vs Native CAV21 (uncomplexed)

Design

Preclinical

Authors

CXChuan XiaoThe University of Texas at El PasoCBCarol M. BatorUniversity of MinnesotaVBValorie D. BowmanPurdue University West Lafayette

Discussion

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Implication

Reveals conserved picornavirus canyon engagement; extends structural models but remains hypothesis-generating for antiviral strategies.

Structured PICO

P
Population
Coxsackievirus A21 (CAV21) and five-domain ICAM-1 receptor (preclinical structural model)
I
Intervention
Cryoelectron microscopy (cryoEM) image reconstruction of CAV21 complexed with ICAM-1
C
Comparator
Native CAV21 (uncomplexed)
O
Outcome
Structural interaction and binding footprint of ICAM-1 on CAV21

The structural characterization of the CAV21-ICAM-1 complex reveals a conserved receptor binding mechanism among picornaviruses that may trigger viral destabilization.

Cite This Study

Xiao et al. (2001) studied this question.

synapsesocial.com/papers/6a77492d4fe2e6ffd8ec8cf1https://doi.org/10.1128/jvi.75.5.2444-2451.2001
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Also Consider

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