Key result
Severe TBI combined with negative affect was associated with disproportionately smaller error-related negativity amplitudes compared to controls, while posterror positivity did not differ.
Why the study?
Does negative affect disproportionately impair performance-monitoring in survivors of severe TBI compared to controls?
Case-Control (n=40)
Does negative affect disproportionately impair performance-monitoring in survivors of severe TBI compared to controls?
Negative affect disproportionately impairs neural correlates of performance monitoring in survivors of severe TBI, supporting a 'double jeopardy' hypothesis.
Negative affect may warrant screening in severe TBI; supports double jeopardy hypothesis but remains hypothesis-generating.
Survivors of severe traumatic brain injury (TBI) are at increased risk for emotional sequelae. The current study utilized the error-related negativity (ERN) and posterror positivity (Pe) components of the event-related potential (ERP) to test the hypothesis that negative affect disproportionately impairs performance-monitoring following severe TBI. High-density ERPs were acquired while 20 survivors of severe TBI and 20 demographically matched controls performed a single-trial Stroop task. Response-locked ERPs were separately averaged for correct and error trials. Negative affect was measured as the single latent factor of measures of depression and anxiety. Groups did not differ on overall level of negative affect. Control and TBI participants did not differ on error rates as a function of negative affect, but differed in response times. ERP results revealed disproportionately smaller ERN amplitudes in participants with TBI relative to controls as a function of negative affect. Pe amplitude did not differ between groups. Negative affect inversely correlated with ERN amplitude in TBI but not control participants. Overall, results support a "double jeopardy" hypothesis of disproportionate impairments in performance monitoring when negative affect is overlaid on severe TBI.
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Larson et al. (2009) conducted a case-control in Severe traumatic brain injury (n=40). Severe traumatic brain injury and negative affect vs. Demographically matched controls was evaluated on Error-related negativity (ERN) and posterror positivity (Pe) amplitudes. Severe TBI combined with negative affect was associated with disproportionately smaller error-related negativity amplitudes compared to controls, while posterror positivity did not differ.
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