Key result
Preoperative antibiotics within 2 hours of incision were associated with reduced 60-day mortality in elderly patients undergoing general surgery (OR 0.44; 95% CI 0.32-0.60; P<0.0001).
Why the study?
Do preoperative antibiotics reduce death within 60 days from hospital admission in elderly patients undergoing general and orthopedic surgery?
Population
n=1362 Medicare patients in Pennsylvania, aged 65 to 85 years, undergoing general and orthopedic surgery…
Comparison
Preoperative antibiotics administered within 2… vs No preoperative antibiotics administered within…
Design
Case-control
Follow-up
60 days
Authors
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Does not support changing practice from observational data; leaves open need for randomized confirmation in elderly surgical patients.
Case-Control (n=1,362)
Yes
Do preoperative antibiotics reduce death within 60 days from hospital admission in elderly patients undergoing general and orthopedic surgery?
Odds Ratio: 0.44 (95% CI 0.32–0.6)
p-value: p=< 0.0001
Preoperative antibiotics administered within 2 hours of incision are associated with a significantly lower 60-day mortality rate in elderly patients undergoing general surgery.
Silber et al. (2005) conducted a case-control in General and orthopedic surgery (n=1,362). Preoperative antibiotics vs. No preoperative antibiotics was evaluated on Death within 60 days from hospital admission (general surgery) (OR 0.44, 95% CI 0.32-0.60, p=< 0.0001). Preoperative antibiotics within 2 hours of incision were associated with reduced 60-day mortality in elderly patients undergoing general surgery (OR 0.44; 95% CI 0.32-0.60; P<0.0001).
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