Why the study?
Does endogenous ANG II influence baroreflex control of HR and RSNA early in life via AT1 or AT2 receptors in newborn lambs?
Does endogenous ANG II influence baroreflex control of HR and RSNA early in life via AT1 or AT2 receptors in newborn lambs?
In newborn lambs, endogenous ANG II exerts a tonic effect on baroreflex control of HR and RSNA via AT1 receptors, shifting the curves toward higher pressure levels independent of direct effects on arterial pressure.
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AT1 blockade shifts baroreflex curves in newborn lambs; hypothesis-generating for developmental ANG II effects and leaves open human neonatal relevance.
Segar et al. (1997) studied this question.
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