Why the study?
Does catheter-based radiotherapy with 192Ir reduce the composite of death, myocardial infarction, or target-lesion revascularization in patients with previous restenosis after coronary angioplasty?
Population
55 patients with previous restenosis after coronary angioplasty
Comparison
0.76-mm ribbon containing sealed sources of 192Ir vs 0.76-mm ribbon containing sealed placebo sources
Design
RCT, randomly assigned, double-blind
Follow-up
24 months
Authors
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Supports 192Ir brachytherapy for restenosis after angioplasty; confirms benefit in this RCT.
Does catheter-based radiotherapy with 192Ir reduce the composite of death, myocardial infarction, or target-lesion revascularization in patients with previous restenosis after coronary angioplasty?
Catheter-based radiotherapy with 192Ir demonstrates significant clinical benefit at 2 years by reducing target-lesion revascularization and composite clinical events in patients with coronary restenosis.
Teirstein et al. (1999) studied this question.
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