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August 1, 1979Journal of General Virology

Sequence Studies of Poliovirus RNA. IV. Nucleotide Sequence Complexities of Poliovirus Type 1, Type 2 and Two Type 1 Defective Interfering Particles RNAs, and Fingerprint of the Poliovirus Type 3 Genome

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Population

32P-labelled genomes of poliovirus type 1, 2 and 3, and two defective interfering particle RNAs of…

Design

Preclinical

Authors

YLY. F. LeeNational Taiwan UniversityNKN KitamuraSetsunan UniversityANAkio NomotoTokyo Medical and Dental University

Discussion

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Implication

Establishes reference RNA chain lengths for poliovirus and DI particles; extends genomic mapping while leaving clinical relevance open.

Structured PICO

P
Population
32P-labelled genomes of poliovirus type 1, 2 and 3, and two defective interfering particle (DI) RNAs of poliovirus type 1
I
Intervention
Digestion with RNase T1 and separation by two-dimensional gel electrophoresis
O
Outcome
Chain length of poliovirus RNA types and DI RNAssurrogate

The study determined the chain lengths of poliovirus type 1, type 2, and two defective interfering particle RNAs using RNase T1 digestion and gel electrophoresis.

Cite This Study

Lee et al. (1979) studied this question.

synapsesocial.com/papers/6a77583ef6b553d308ae6ee6https://doi.org/10.1099/0022-1317-44-2-311
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polynucleotide sequence homologies among polioviruses.1968 · 22 citations
  2. 2Defective Interfering Particles of Poliovirus I. Isolation and Physical Properties1971 · 151 citations
  3. 3Molecular Weight of Poliovirus Ribonucleic Acid1969 · 108 citations
  4. 4Covalent linkage of a protein to a defined nucleotide sequence at the 5'-terminus of virion and replicative intermediate RNAs of poliovirus.1977 · 348 citations