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November 1, 1971Proceedings of the National Academy of SciencesOpen Access

Determination of the Gene Sequence of Poliovirus with Pactamycin

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Population

Poliovirus-infected cells

Design

Preclinical

Authors

DSDonald F. SummersUniversity of OtagoJMJacob V. MaizelWestern University

Discussion

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Implication

Supports early viral genome mapping in model systems; leaves open confirmation and clinical translation without higher-level evidence.

Structured PICO

P
Population
Poliovirus-infected cells
I
Intervention
Pactamycin
O
Outcome
Location of virus coat proteins and assignment of coat protein cistron

Pactamycin was used to tentatively map the poliovirus coat protein cistron to the 5' end of the viral RNA.

Cite This Study

Summers et al. (1971) studied this question.

synapsesocial.com/papers/6a77583ef6b553d308ae6efdhttps://doi.org/10.1073/pnas.68.11.2852
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells.1965 · 362 citations
  2. 2Molecular Weight of Poliovirus Ribonucleic Acid1969 · 108 citations
  3. 3Polypeptide cleavages in the formation of poliovirus proteins.1968 · 351 citations
  4. 4Specific cleavage of viral proteins as steps in the synthesis and maturation of enteroviruses.1968 · 153 citations
  5. 5Unexpectedly Large Size of Globin Messenger Ribonucleic Acid1971 · 84 citations