Characterization of ribonuclease-resistant RNA from poliovirus-infected HeLa cells.

J. Michael Bishop; Donald F. Summers; Leon Levintow

doi:10.1073/pnas.54.4.1273

October 1, 1965Proceedings of the National Academy of SciencesOpen Access

Characterization of ribonuclease-resistant RNA from poliovirus-infected HeLa cells.

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Key Points

To identify and characterize ribonuclease-resistant forms of viral RNA produced during poliovirus infection in HeLa cells.
Infected cultured HeLa cell lines with poliovirus.
Isolated cellular and viral RNA fractions following infection.
Treated viral RNA preparations with ribonuclease enzymes to assess resistance and structural properties.
Identified distinct ribonuclease-resistant RNA species unique to poliovirus-infected HeLa cells.
Demonstrated that resistant RNA forms represent double-stranded replication intermediates essential for poliovirus genome synthesis.

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Implication

Demonstrates the isolation of ribonuclease-resistant RNA in poliovirus-infected HeLa cells, suggesting the formation of viral replication intermediates.

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Bishop et al. (1965) studied this question.

synapsesocial.com/papers/6a77583ff6b553d308ae6f07 https://doi.org/10.1073/pnas.54.4.1273

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Characterization of ribonuclease-resistant RNA from poliovirus-infected HeLa cells.

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Characterization of ribonuclease-resistant RNA from poliovirus-infected HeLa cells.

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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